The goal of an AIDS-free generation may be ambitious, but it is possible with the knowledge and interventions we have right now. Imagine what the world will look like when we succeed.
Former Secretary of State Hillary Clinton,
November 8, 2011

What is an AIDS-free generation?

  1. Virtually no child anywhere will be born with the virus.
  2. As children and teenagers become adults, they will be at significantly lower risk of ever becoming infected than they would be today no matter where they are living.
  3. If people do acquire HIV, they will have access to treatment that helps prevent them from developing AIDS and passing the virus on to others.
  4. HIV may be with us into the future until we finally achieve a cure or a vaccine, but the disease that HIV causes need not be with us.
As recently as 10 years ago, it seemed like AIDS would be a death sentence for an entire continent.... Well, the tide has turned."
Secretary of State John Kerry

The challenge to achieve an AIDS-free generation had been issued. By virtue of the significant strides made across the HIV continuum in the past decade, it was realizable. But first, PEPFAR needed a strategy that would encourage donors and country governments to stand behind the international effort to end AIDS now that this distant goal was finally attainable.

A Blueprint for an AIDS-free Generation

Cover: PEPFAR Blueprint

At the 19th International Conference on AIDS in Washington, D.C., Secretary Clinton signaled the upcoming release of a blueprint: The PEPFAR Blueprint: Creating an AIDS-free Generation.

Released just before World AIDS Day in 2012, the Blueprint included four roadmaps–for saving lives, for smart investments, for shared responsibility, and for driving results with science–and identified key action steps for each.

The Blueprint also underscored the importance of partnering with countries and their communities to achieve this goal.

Delivering on the Promise of an AIDS-free Generation

In the years following the release of the Blueprint, PEPFAR and USAID initiatives made significant strides toward the goal of an AIDS-free generation. As of December 2014, together, we have supported:

people with lifesaving HIV treatment

749, 000⁺
HIV-positive women with prevention of mother-to-child transmission services resulting in 95 percent of their babies born HIV-free

people with HIV testing services

number of voluntary medical male circumcision procedures PEPFAR has performed

On World AIDS Day 2014, under the leadership of President Obama and Office of the Global AIDS Coordinator Ambassador Deborah Birx, PEPFAR announced the next stage in its vision: PEPFAR 3.0: Delivering on the Promise of an AIDS-free Generation.

Puzzle: Five action agendas-Impact, Efficiency, Sustainability, Partnership, and Human Rights

Now in its third phase (2013 to present), PEPFAR is focusing on accelerating core interventions to control the epidemic and investing resources strategically to reach key high-risk populations with evidence-based programs. PEPFAR 3.0 specifies five action agendas—Impact, Efficiency, Sustainability, Partnership, and Human Rights—as the foundation for achieving an AIDS-free generation.

The Strengthening High Impact Interventions for an AIDS-free Generation Project (AIDSFree)

Announced at the 2014 International Conference on AIDS in Melbourne, Australia, the Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree) Project is a five-year cooperative agreement funded by PEPFAR and managed by USAID's Office of HIV/AIDS. It will run from 2014 to 2019.

Building on the momentum of USAID and PEPFAR's investments to bring about an AIDS-free generation, AIDSFree:

Disseminates relevant information through knowledge management

Identifies opportunities to support scale-up and pilot of new approaches/initiatives in geographic priority areas

Develops evidence-based tools, protocols, and standard operating procedures

Monitors and evaluates interventions, supporting data collection, analysis, and utilization

Facilitates organizational capacity assessments and follow-up

Utilizes gender analysis to target appropriate interventions

Facilitates south-to-south technical exchanges

Engages the private sector to foster and develop public-private partnerships

AIDSFree's team of partners brings expertise in the following cross-cutting areas:

Quality Improvement
Gender Analysis and Programming
Private Sector Engagement
Capacity Development
South-to-south Collaboration
Community Engagement
Faith-Based and Health Systems Strengthening

AIDSFree is working globally by making smart investments in the following core focus areas:


Our Impact

AIDSFree works closely with country governments, civil society, and the private sector to address the critical pillars of HIV and public health. Countries can work with AIDSFree by working with the appropriate USAID Mission.

PEPFAR Focus Countries: The American people, through PEPFAR, support the fight against global AIDS through bilateral and regional programs in 65 countries. As a result of this commitment, the U.S. supported life-saving treatment for 6.7 million men, women and children worldwide.
HIV Prevalence among adults from 1990 to 2014 is highest in the southern region of Africa as well as some countries in West Africa. Most countries in South America have a low HIV prevalence along with a few countries in northern Europe and the Middle East.

AIDSFree is currently working on the following country initiatives:

Our Partners

AIDSFree is led by JSI Research & Training Institute, Inc., together with seven partners that have made significant contributions to the global AIDS response over the past three decades.

Affiliated Projects

AIDS Support and Technical Assistance Resources, Task Order 1 (AIDSTAR-One)

2008 to 2014

AIDSTAR-One leveraged the expertise of its diverse partner organizations to support the U.S. Government's commitment to combat HIV through technical assistance and knowledge management.

Applying Science to Strengthen and Improve Systems (ASSIST)

2012 to 2017

The objective of the USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project is to improve the quality and outcomes of health care and other services by enabling host country providers and managers to apply the science of improvement.

Health Communication Capacity Collaborative (HC3)

2012 to 2017

The Health Communication Capacity Collaborative (HC3) is a five-year, global project funded by USAID. It is designed to strengthen developing country capacity to implement state-of-the-art social and behavior change communication (SBCC) programs.

Health Policy Project (HPP)

2010 to 2015

The Health Policy Project (HPP) works to strengthen developing country national and subnational policy, advocacy, governance, and finance for strategic, equitable, and sustainable health programming.

Linkages Across the Continuum of HIV Services for Key Populations Affected by HIV (LINKAGES) Linkages

2014 to 2019

Linkages aims to strengthen the ability of partner governments, key population (KP) civil society organizations, and private sector providers to effectively deliver comprehensive, high-quality HIV prevention, treatment, and care services for KPs and their partners.

Maternal and Child Health Integrated Program (MCHIP)

2008 to 2014

MCHIP addresses the barriers to accessing and using key evidence-based interventions across the life stages—from pre-pregnancy to age 5—by linking communities, primary health facilities and hospitals.

Southern Africa’s Capacity Development & Support Project (CDS)

2014 to 2019

The CDS aims to mitigate the impact of HIV and AIDS by increasing local partner capacity and supporting the South African Government.


2012 to 2017

STRIVE is a research consortium investigating the social norms and inequalities that drive HIV. STRIVE is funded by UKaid from the Department for International Development.

Supply Chain Management System (SCMS)

2005 to 2015

SCMS strengthened and established secure, reliable, cost effective and sustainable supply chains to meet the care and treatment needs of people living with or affected by HIV and AIDS.

Supporting Operational AIDS Research (SOAR)

2014 to 2019

The Supporting Operational AIDS Research (SOAR) project aims to conduct operational HIV and AIDS research, promote utilization and dissemination of data, and build the capacity of local organizations to conduct operational research.

The Capable Partners Program (CAP) Mozambique

2003 to 2013

The Capable Partners Program (CAP) Mozambique strengthened the organizational and technical capacities of nongovernmental organizations (NGOs) working in HIV and AIDS prevention and service delivery and expanded the HIV prevention tools available to local organizations facilitating community discussions about HIV in the provinces of Maputo, Sofala, Zambezia, Nampula and Manica.

The Initiative on Girls’ Vulnerability to HIV (known as the Go Girls! Initiative)

2007 to 2011

Implemented in Mozambique, Botswana, and Malawi, this initiative employed a multi-sectoral, integrated program utilizing the following program elements: community mobilization; improving adult-child communication skills; use of reality radio; school- and community-based life skills; assisting teachers and principals to create a safe school environment; and girls’ economic strengthening activities.

The Male Norms Initiative

2007 to 2010

Implemented in Ethiopia, Namibia, and Tanzania, the initiative built the capacity of in-country partners to integrate male engagement (ME) strategies into their HIV programs through training, materials development, network development, and policy review.

The Special Initiative on Sexual Gender-Based Violence

2007 to 2010

Implemented by 10 PEPFAR partners in Rwanda and Uganda, this initiative complemented efforts to expand sexual violence services, improve service quality, increase service demand and uptake, and provides an evidence base for scaling-up such efforts in the future.

For USAID Missions

AIDSFree can accept funds from any USAID mission. The process is delineated below.

  1. Step 1Country expresses interest and informs USAID Mission
  2. Step 2USAID Mission contacts USAID Washington – concept note is developed
  3. Step 3USAID Washington contacts AIDSFree about country interest
  4. Step 4AIDSFree reviews concept note and provides comments within 2-3 days
  5. Step 5Country team, USAID, and AIDSFree develop scope of work (SOW)
    with budget and timeline within 2 weeks
  6. Step 6USAID Mission and USAID Washington approve SOW
  7. Step 7AIDSFree initiates support for approved activities in-country

For more information on this process, please contact:
Nida Parks
Agreement Officer’s Representative (AOR)
U.S. Agency for International Development, Washington, D.C. United States

JSI Research & Training Institute, Inc.
1616 Fort Myer Drive, 16th Floor
Arlington, Virginia 22209