Health care waste (HCW) poses serious risks to public health and the environment. Because of limited resources and political will, health care waste management (HCWM) often does not receive sufficient attention. This training manual focuses on HCWM as an infection prevention and control (IPC) measure. It addresses key aspects of infection control in everyday practice, and outlines risk assessment and minimization of infection transmission in a variety of settings. This manual can be used by waste handlers in public and private health care settings to increase appropriate knowledge, skills, and attitudes relevant to best practices in IPC and HCWM.