Kigozi, G., Musoke, R., Kighoma, N., et al. BJU International (January 2014), 113(1): 127–132.
MMC is recommended as an HIV prevention intervention for HIV-negative men to reduce their risk of HIV acquisition. HIV-positive men may seek MMC services, so it was important to determine if MMC is safe for HIV-positive men with low CD4 counts. This study assessed completed wound healing following medical male circumcision (MMC) among HIV-negative and HIV-positive men. The study enrolled 439 men aged 12 and older: 262 HIV-negative and 177 HIV-positive men with CD-4 viral counts below 350 and ≥350 cells/mm. Data on demographic characteristics and behavior were collected at baseline, and blood samples were tested for HIV and CD4 counts. At weekly follow-up visits, participants were asked about behavior and assessed for wound healing. The study found no statistically significant differences in healing by HIV status or CD4 count. The median time to complete healing was four weeks, and all participants were fully healed by six weeks following MMC. At four weeks, 22.7 percent had resumed sexual activity before complete wound healing. The authors noted the importance of reinforcing messages about condom use and complete wound healing before resuming sex. They concluded that including HIV-positive men in MMC services would not adversely affect wound healing, and that HIV-positive men should not be excluded from MMC services.