Below are administration tips and special situations for administering LPV/r pellets. Download a PDF of this page [PDF, 158KB] to use offline.

Administration Tips

  • Capsules must be opened to take out pellets. Capsules should NOT be swallowed; only the pellets inside should be swallowed.
  • Pellets must be taken whole. They cannot be stirred, broken, crushed, chewed, or dissolved. Doing so may make the medication no longer work.
  • Doses should be given approximately 12 hours apart. Try to align with meal times, but if given at other times, include a small snack or breast milk.
  • Try to make sure there are no distractions during administration, which will take 1 to 5 minutes.
  • Make sure your hands are dry when opening the capsules. Otherwise, the capsules may become sticky and will be difficult to open.
  • Hold the capsule so that the yellow half is on top. Tap the capsule to get pellets to the bottom and ensure that all pellets will come out.
  • Give 1 or 2 capsules of pellets at a time, depending on the child's age. Three or more capsules of pellets at once will be too much for the child to swallow.
  • If the child doesn't want to take the pellets or is spitting them out, try giving fewer pellets in each spoonful.
  • Make sure all pellets are swallowed and no pellets fall off the spoon. If they fall off the spoon, pick them up with dry fingers and put them back on the spoon.
  • Remember to keep the medication out of reach of children in the house.
  • Special Situations
    • If the child misses a dose of LPV/r pellets, give the dose as soon as possible; but if it is more than 6 hours later, skip the missed dose and just give the next dose at the regular time. Do not give two doses at the same time to make up for a missed dose. If you are unsure whether or not to administer the dose, call your health care worker.
    • If your child vomits or spits up immediately following a dose of LPV/r pellets and the pellets can be seen in the vomit, re-administer a new dose of pellets. If more than 15 minutes have passed and the pellets cannot be seen in the vomit or spit, you do not have to re-administer the pellets.
    • Notify your health care provider if your child looks different after starting LPV/r as some of the side-effects may be rare but serious. This may include if they are eating less, have yellow colored skin or eyes, light-colored stool, dark-colored urine, itchy skin, appears to have stomach pain, is repeatedly vomiting, or faints.

For Babies who are Exclusively Breastfeeding or on Formula

Babies who are 3 to 6 months old should still be exclusively breastfeeding or on formula and not yet taking solid foods. The instructions below explain how to give pellets in breast milk or formula.

  • Giving Pellets to Breastfeeding Babies
    1. Remove the prescribed number of capsules from the bottle. Place on a clean, dry plate.
    2. Express approximately one cup of breast milk into a clean cup or bowl.
    3. To open, hold each capsule upright. The pellets should be in the clear bottom half. Gently twist the top yellow half of the capsule to open.
    4. Pour pellets into a clean, dry spoon. If the spoon is damp, pellets will cling to the spoon. The spoon needs to be dried after each spoonful.
    5. Add a small amount of breast milk on top of the pellets. Do not mix or try to dissolve.
    6. Holding baby comfortably, pour the pellets into baby's mouth immediately (press baby's chin gently to encourage baby to open mouth).
    7. Check baby's mouth to make sure all pellets are swallowed.
    8. Repeat until all capsules for the dose are finished.
    9. Immediately have baby breastfeed for few minutes. (Stroke baby's cheek or under baby's chin to encourage baby to start sucking and swallowing).
    10. Give baby any other prescribed medications.
    11. Dispose of the empty capsules in routine waste.
    12. Remember to keep the medication out of reach of children in the house.
  • Giving Pellets to Babies with Expressed Breast milk or Formula
    1. Remove the prescribed number of capsules from the bottle. Place on a clean, dry plate.
    2. Express approximately one cup of breast milk or pour small amount of formula into a clean cup or bowl.
    3. To open, hold each capsule upright. The pellets should be in the clear bottom half. Gently twist the top yellow half of the capsule to open.
    4. Pour pellets into a clean, dry spoon. If the spoon is damp, pellets will cling to the spoon. The spoon needs to be dried after each spoonful.
    5. Add a small amount of breast milk or formula on top of the pellets. Do not mix or try to dissolve.
    6. Holding baby comfortably, pour the pellets into baby's mouth immediately (press baby's chin gently to encourage baby to open mouth).
    7. Repeat until all capsules for the dose are finished.
    8. Encourage baby to swallow more breast milk or formula to make sure the baby has swallowed all pellets.
    9. Check the baby's mouth to be sure no pellets remain. If pellets remain, repeat previous step.
    10. Give the baby any other prescribed medications.
    11. Dispose of the empty capsules in routine waste.
    12. Remember to keep the medication our of reach of children in the house.

For Children Taking the Pellets with Age-Appropriate Soft Food or Liquid

Children who are older than 6 months may take LPV/r pellets with age-appropriate soft food or liquid.

  • Giving Pellets with Soft Food
    1. Prepare food to give to child with the pellets. Food should be soft and not require chewing. Choose a food the child enjoys and will swallow. Porridge or yoghurt are good examples of soft foods.
    2. Place a small amount of food in a spoon, a small cup, or a bowl.
    3. Remove the prescribed number of capsules from the bottle. Place on a clean, dry plate.
    4. To open, hold each capsule upright. The pellets should be in the clear bottom half. Gently twist the top yellow half of the capsule to open.
    5. Pour pellets on top of the food. Cover pellets with additional food, but do not mix.
    6. Spoon food into child's mouth immediately. Encourage the child to swallow pellets whole and to not chew the food.
    7. Repeat steps until the child has swallowed the pellets from all of the prescribed capsules.
    8. Encourage the child to eat a bit more after swallowing the pellets.
    9. Check to make sure no pellets remain in the child's mouth.
    10. Dispose of the empty capsule in routine waste.
    11. Do not store a mixture of the pellets and food for later use.
    12. Remember to keep the medication our of reach of children in the house.
  • Giving Pellets with Liquid
    Graphic of a baby being fed a spoonful of breast milk and pellets
    1. Prepare liquid to give to child with the pellets. Milk or water are good examples of liquid to use to give the pellets. Pellets should not be taken with juice or carbonated drinks like soda.
    2. Remove the prescribed number of capsules from the bottle. Place on a clean, dry plate.
    3. To open, hold each capsule upright. The pellets should be in the clear bottom half. Gently twist the top yellow half of the capsule to open.
    4. Pour pellets onto a clean, dry spoon. If the spoon is damp, pellets will cling to the spoon. The spoon needs to be dried after each spoonful.
    5. Pour a small amount of liquid on top of the pellets. Do not mix or try to dissolve.
    6. Spoon liquid into child's mouth immediately. If pellets sit in the liquid, they will become sticky and develop a bad taste, and may not work as intended.
    7. Repeat steps until the child has swallowed the pellets from all of the prescribed capsules.
    8. Encourage the child to drink a bit after swallowing the pellets.
    9. Check to make sure no pellets remain in the child's mouth. If pellets remain, repeat previous step.
    10. Give the child any other prescribed medications.
    11. Dispose of the empty capsules in routine waste.
    12. Remember to keep the medication our of reach of children in the house.