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From a supply chain perspective, each of the “90's” has possible complications and roadblocks towards realizing the promise envisioned by 90-90-90—for example, to monitor those on treatment means an unprecedented scale-up of viral load testing throughout Africa. This article highlights strategies to strengthen the global supply chain system to reach the UNAIDS 90-90-90 targets by 2020. In addition, the article highlights the need for integrated planning, efficient procurement, and supply chain management system.